Intrinsic Factor

Authors:
  • VHVictor Herbert
    Victor Herbert
  • WCWilliam B. Castle
    William B. Castle
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Abstract
THE demonstration,1 in 1929, that normal human gastric juice contained an "intrinsic factor" that, given simultaneously with an "extrinsic factor" present in beef muscle, caused an erythropoietic response in pernicious anemia initiated a laborious form of clinical investigation attractive to few. When, in 1948, it was shown2 that the active principle of purified liver extracts, vitamin B12, was also the so-called extrinsic factor, interest quickened. In 1952, after the preparation3 of vitamin B12 labeled with radioactive cobalt (Co60), Heinle and his associates4 demonstrated that in pernicious anemia, intrinsic factor enhanced the assimilation of the radioactive tracer, . . .

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