Two consecutive seasons of screenhouse trials were conducted at the National Horticultural Research Institute (NIHORT) Ibadan to determine the pathogenicity of Meloidogyne incognita on five lines of fluted pumpkin (EN 2000 – 4, EN 2000-6, EN2000-10, EN2000-11, EN2000-13) and efficacy of 50 and 75% aqueous extracts from the leaves of Morinda lucida and Cassia acutifolia as compared with that of 2.5kg a.i/ha Carbofuran in the nematode control. Control experiment was also set up which was devoid of any treatment. Experimental design was a factorial type fitted into a complete randomized design. Results from the study revealed that development and vegetative growth of plants treated for nematode control were significantly better (PTelfairia lines but rather improved their growth and vegetative performance. Significant differences were also observed among the Telfairia lines. EN2000-4 exhibited overall superiority over the other lines while EN2000-13 recorded significantly higher gall index than the other lines though it did not differ significantly from EN2000-6, EN2000-10 and EN2000-11 in terms of vine length, vine girth and number of leaves. EN2000-13 thus exhibited a higher level of susceptibility to the root knot nematode, Meloidogyne incognita. Keywords: Meloidogyne incognita, pathogenicity, control, plant extracts, carbofuran.