A Sonopiezoelectric Z-Scheme Nanoplatform Synergizing Trace Ag + for Eradicating Methicillin-Resistant Staphylococcus aureus -Induced Pneumonia

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Abstract
The underlying mechanisms by which heterogeneous interfaces enhance piezoelectric catalytic effects under ultrasonic irradiation, along with their potential biomedical applications, remain poorly understood. In this study, a versatile Z-Scheme nanoplatform by encapsulating the BiO2-x/Ag3PO4 heterojunction within poly(lactic-co-glycolic acid) (PLGA) microspheres (BA@PLGA) was developed for ultrasound-activated deep-lung antibacterial therapy. The Z-scheme heterojunction synergistically integrates piezoelectric and built-in electric fields, achieving 2.2 and 4.7-fold enhancements in piezoelectric (d33) and electromechanical coupling (k) coefficients, respectively. Ultrasonic-induced dynamic modulation of the piezoelectric potential in BiO2-x/Ag3PO4 generated a "carrier-pumping" effect, which enhanced polarized charge migration efficiency and thereby markedly amplified reactive oxygen species (ROS) production. Consequently, with the assistance of trace Ag+, 99.87 ± 0.05% of methicillin-resistant Staphylococcus aureus (MRSA) were effectively eradicated within 15 min in vitro. Prokaryotic transcriptome analysis further revealed that the synergistic effect of ROS and trace Ag+ disrupted the cell envelope and interfered with the core metabolic pathways of MRSA. This ultrasound-activated platform, integrating piezocatalysis and trace Ag+, achieved over 99.9% bacterial clearance rapidly (1.6log superiority over gentamicin) and alleviated inflammation in a MRSA-induced pneumonia, demonstrating considerable potential for combating bacterial infections in deep-seated tissues.
Funding Information
  • Natural Science Foundation of Tianjin Municipality (20JCZDJC00580)
  • China National Funds for Distinguished Young Scientists (51925104)
  • Natural Science Foundation of Beijing Municipality (7232338)
  • Natural Science Foundation of Beijing Municipality (L242040)
  • Wuhan University of Technology (2024-KF-)
  • National Natural Science Foundation of China (32371388)
  • National Natural Science Foundation of China (52401307)
  • National Natural Science Foundation of China (U21A2084)
  • Natural Science Foundation of Guangdong Province (U21A2084)

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