Base-Promoted Nucleophilic Phosphorylation of Benzyl Fluorides via C(sp3)–F Cleavage
- 7 August 2024
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 89 (16) , 11739-11746
Abstract
Herein, a transition-metal-free phosphorylation of benzyl fluorides with P(O)-H compounds is disclosed. In the presence of t BuOK, various benzyl fluorides react with P(O)-H compounds to produce the corresponding benzyl phosphine oxides, phosphinates, and phosphonates in good to high yields. This base-promoted phosphorylation reaction offers a facile and general strategy for the construction of a C(sp(3))-P bond.Keywords
Funding Information
- Fundamental Research Funds for Central Universities of the Central South University
- Natural Science Foundation of Hunan Province (2019JJ50748, 2022JJ20055)
- National Natural Science Foundation of China (21902185)
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