Recent Advances in Activatable 19F Magnetic Resonance Imaging Nano‐Probes for the Detection of Biomarkers

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Abstract
Adapting MRI to the field of molecular imaging is a challenge that continues to attract considerable attention. The detection of a given biomolecular analyte requires the availability of a molecular probe that is able to respond with a sufficient signal gap in order to overcome the low sensitivity of MRI. To this end, 19F MRI has yielded promising results due to its negligible endogenous background signals. Several small molecular probes have been reported; however, the low sensitivity of 19F MRI render the detection of biomarkers in vivo difficult, in view of their sub‐nanomolar concentration on site. Researchers have thus directed their attention toward larger chemical objects containing large numbers of 19F nuclei as smart platforms that allow a stimuli‐induced response. This article discusses the recent advances and future directions in the design of nano‐probes that respond to chemical or physical stimuli recognized as biomarkers for life and disease.
Funding Information
  • Japan Society for the Promotion of Science (PE21713, JP21H04706, JP20K05747, JP21H00401, JP22H05425)

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