Development of Nanosystems to Release Atenolol

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Abstract
The structure of aluminum monohydroxide resulting from synthesis by ammonium hydroxide with aluminum chloride (or aluminum nitrate, for example) by a sol-gel process, gives a purified and chemically inert material with many applications possibilities because of its great specific surface area. A pseudoboehmite is the choice in this project for adsorption/desorption of atenolol. The molecular interaction with the pseudoboehmite substrate was studied by FTIR (Infrared Spectroscopy), DSC (Scanning electron /TG Thermogravimetry), UV-vis (Ultraviolet-visible spectroscopy) and SEM (Scanning Electron Microscopy). The SEM characterization has been used to quantify the local structural surface for the correlations with the synthesis process; and the Spectroscopies and Thermogravimetric techniques were used for measurements of the adsorption/desorption concentrations of the drug in physiological solution. This procedure gives information to the chemistry and surface of these fine ceramics material that would be applied like excipient in medications to control the drug delivery and plasmatic concentrations in optimal conditions.

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