Mitochondrial control of innate immune signaling by irradiated cancer cells
Open Access
- 1 January 2020
- journal article
- editorial
- Published by Taylor & Francis in OncoImmunology
- Vol. 9 (1) , 1797292
Abstract
Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of mitochondrial DNA to the cytosol, hence setting off CGAS-driven type I IFN synthesis. These data point to the existence of a therapeutically actionable mitochondrial checkpoint that restricts innate immune signaling in irradiated cancer cells.Keywords
Funding Information
- US Department of Defense
- Breast Cancer Research Program (#ZP-6177, PI: Formenti)
- Leukemia and Lymphoma Society
- Department of Radiation Oncology at Weill Cornell Medicine
- Luke Heller TECPR2 Foundation
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