Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans
Authors:
- 1 February 2018
- journal article
- review article
- Published by Elsevier in Drug Metabolism and Pharmacokinetics
- Vol. 33 (1) , 9-16
Abstract
No abstract availableKeywords
Funding Information
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- U.S. Public Health Service (P42ES010337, GM086713)
This publication has 103 references indexed in Scilit:
- Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemiaScientific Reports, 2013
- Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 miceHepatology, 2012
- Reduced Expression of UGT1A1 in Intestines of Humanized UGT1 Mice via Inactivation of NF-κB Leads to HyperbilirubinemiaGastroenterology, 2012
- Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanatesBiopharmaceutics & Drug Disposition, 2011
- A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent GlucuronidationDrug Metabolism and Disposition, 2010
- Developmental hyperbilirubinemia and CNS toxicity in mice humanized with theUDP glucuronosyltransferase 1(UGT1) locusProceedings of the National Academy of Sciences, 2010
- Comparison of the Drug-Drug Interactions Potential of Erlotinib and Gefitinib via Inhibition of UDP-GlucuronosyltransferasesDrug Metabolism and Disposition, 2010
- Identification of UDP Glycosyltransferase 3A1 as a UDP N-AcetylglucosaminyltransferaseJournal of Biological Chemistry, 2008
- Humanized Mouse Lines and Their Application for Prediction of Human Drug Metabolism and Toxicological Risk AssessmentThe Journal of Pharmacology and Experimental Therapeutics, 2008
- Identification of UDP-glucuronosyltransferase 1A10 in non-malignant and malignant human breast tissuesSteroids, 2008