Harnessing Proton as a Performance Amplifier in Nanozyme Catalysis for Ultrasensitive Detection

Authors:
Publisher website
Google Scholar
Abstract
Peroxidase‐mimicking nanozymes have revolutionized biomedicine and environmental catalysis, but their pH‐dependent catalytic behavior remains a blind spot in activity evaluation and application design. Here, a framework is presented for understanding and harnessing pH effects through a synergistic interplay of interfacial electrostatics and proton‐coupled electron transfer (PCET) process. Contrary to the entrenched “pH 4.0 gold standard,” the proposed multi‐index evaluation matrix for activity evaluation reveals that platinum nanozymes achieve peak activity at pH 2 ⁺) at pH 2.5, a 47‐fold increase in glutathione determination sensitivity is achieved over the traditional single‐electron oxidation product (TMB⁺ • ) analysis at pH 4.0. This study not only recalibrates nanozyme evaluation benchmarks but also pioneers proton‐engineered catalysis for environmental applications.
Funding Information
  • Key Programme (22336002)
  • National Science Fund for Distinguished Young Scholars (22425603)

This publication has 37 references indexed in Scilit: