Alteration of the intestinal microbiome: fecal microbiota transplant and probiotics forClostridium difficileand beyond
Authors:
- Elizabeth K BroussardEBElizabeth K Broussard
- Christina M SurawiczCSChristina M Surawicz
- 1 September 2013
- journal article
- review article
- Published by Taylor & Francis in Expert Review of Gastroenterology & Hepatology
- Vol. 7 (7) , 615-628
Abstract
Clostridium difficile infection is increasingly common with a high risk of recurrence despite antibiotic treatment. In cases of recurrent C. difficile infection, fecal microbiota transplant (FMT) is a highly effective treatment option promoting the restoration of normal gut microbiota. Furthermore, preliminary uncontrolled evidence demonstrates possible benefit of FMT in the management of some cases of inflammatory bowel disease and chronic constipation. In addition to presenting an overview of FMT, we discuss the role of probiotics, a more common approach to modifying the intestinal microbiome. Probiotics have been utilized broadly for many disease processes, including gastrointestinal, cardiovascular and allergic disease settings, although with limited and inconsistent results. Multiple potential areas for research are also identified.Keywords
This publication has 139 references indexed in Scilit:
- Probiotic yogurt improves antioxidant status in type 2 diabetic patientsNutrition, 2012
- Treating Clostridium difficile Infection With Fecal Microbiota TransplantationClinical Gastroenterology and Hepatology, 2011
- Gut microbiota, probiotics, and vitamin D: Interrelated exposures influencing allergy, asthma, and obesity?Journal of Allergy and Clinical Immunology, 2011
- Treatment of Relapsing Mild-to-Moderate Ulcerative Colitis With the Probiotic VSL#3 as Adjunctive to a Standard Pharmaceutical Treatment: A Double-Blind, Randomized, Placebo-Controlled StudyAmerican Journal of Gastroenterology, 2010
- Probiotic Lactobacillus paracasei effect on cariogenic bacterial floraClinical Oral Investigations, 2010
- Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study A patient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trialEuropean Journal of Clinical Nutrition, 2010
- Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical dataClinical and Experimental Immunology, 2010
- Characterization of oral lactobacilli as potential probiotics for oral healthOral Microbiology and Immunology, 2008
- Short-term effect of ice-cream containingBifidobacterium lactisBb-12 on the number of salivary mutans streptococci and lactobacilliActa Odontologica Scandinavica, 2008
- Human gut microbes associated with obesityNature, 2006