Genetic Determination of Phenotypic Variation in Sickle Cell Trait
Authors:
- 25 August 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 177 (4050) , 716-718
Abstract
Two genetic sources of variation influence the percentage of sickle cell hemoglobin found in heterozygotes. One factor is strongly related to the percentage of hemoglobin S in the carrier parent and appears to be determined by sickle hemoglobin isoalleles, whereas the other is related to racial background and may well be polygenic.Keywords
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