Nanoparticles and Spermatogenesis: How Do Nanoparticles Affect Spermatogenesis and Penetrate The Blood–Testis Barrier
Authors:
- 4 April 2012
- journal article
- review article
- Published by Taylor & Francis in Nanomedicine
- Vol. 7 (4) , 579-596
Abstract
Due to the widespread use of nanomaterials in medical, industrial and military applications, the question as to whether nanoparticles (NPs) cause harmful disturbances in human health, especially on the reproductive system, remains a matter of concern. In this review, we focus mainly on the in vivo and in vitro effects of NPs on spermatogenesis at the clinical, cellular and molecular levels. In general, most NPs display adverse effects on spermatogenesis at these various levels; but, some NPs show no adverse effects. However, the mechanism underlying NP disruption of spermatogenesis and penetration of the blood-testis barrier remains unclear. In this review, we raise many hypotheses for experimental testing in order to elucidate the mechanism.Keywords
This publication has 78 references indexed in Scilit:
- Nanoparticles in Measurement ScienceAnalytical Chemistry, 2011
- Protective effects of nanostructures of hydrated C60 fullerene on reproductive function in streptozotocin-diabetic male ratsToxicology, 2011
- Effect of sodium selenite, Se-yeast and nano-elemental selenium on growth performance, Se concentration and antioxidant status in growing male goatsSmall Ruminant Research, 2011
- Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertilityNature Nanotechnology, 2010
- Subchronic oral toxicity of silver nanoparticlesParticle and Fibre Toxicology, 2010
- Nanoparticle-rich diesel exhaust may disrupt testosterone biosynthesis and metabolism via growth hormoneToxicology Letters, 2009
- Molecular aspects of male fertilityEMBO Reports, 2009
- Identification of the mechanisms that drive the toxicity of TiO2 particulates: the contribution of physicochemical characteristicsParticle and Fibre Toxicology, 2009
- A subchronic toxicity study of elemental Nano-Se in Sprague-Dawley ratsLife Sciences, 2005
- NF-κB and TNF-α stimulate androgen receptor expression in Sertoli cellsMolecular and Cellular Endocrinology, 2003