Prognostic factors for pain relief after CT-guided radiofrequency ablation of osteoid osteoma: a 13-year retrospective study

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Abstract
Purpose The aim of this study is to evaluate the treatment response of patients with osteoid osteoma (OO) following radiofrequency ablation (RFA) and identify factors influencing the time to complete pain relief post-treatment. Materials and methods This is a retrospective cohort study of patients who underwent RFA for OO between 2010 and 2023. Demographic, clinical data, and time between symptoms onset to diagnosis and RFA were recorded. CTs were reviewed for OO location (upper extremity, lower extremity, spine/pelvis), intra-articular versus extra-articular lesions, nidus size, degree of peripheral bone formation, and presence of vessel sign. Procedural related information included needle approach, RFA active tip length, and number of RFA cycles. Statistical analysis was made on factors and their correlation to complete pain relief. Results Out of 63 patients included in our study (mean age 19.3 ± 10.6), OO were located in the upper extremity (n = 7, 11%), lower extremity (n = 48, 76%), and pelvis/spine (n = 8, 13%). OO in the pelvis/spine achieved the quickest complete pain relief (14 days) compared to those in lower (25 days, 11 days longer) and upper extremity (54 days, 40 days longer) respectively (p = 0.04). Vessel sign had significant association with shorter time to complete pain relief (p = 0.03). Longer duration of symptoms until diagnosis or RFA, larger nidus, more bone formation, and extra-articular OO responded slower to RFA, though statistical significance was not reached. Conclusions Anatomical location and certain imaging characteristics of OO may have association with time to complete pain relief following RFA. The findings can potentially help optimizing patient counseling with more realistic expectations and symptom management strategies prior to and following RFA.

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