National probabilistic risk assessment of newly registered pesticides in agricultural products to propose maximum residue limit (MRL)

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Abstract
Following the EPA recommended method, a chronic diet risk assessment for pesticides was recently performed for adults and children in the Iranian population. The National Theoretical Maximum Daily Intake (NTMDI) for 32 pesticides was computed using the theoretical maximum residue limits (MRLs) of food consumption regulations and data from the comprehensive database of the Iranian Research Institute of Plant Protection (IRIPP). The risk was assessed by comparing TMDI with the acceptable daily intakes (ADI) evaluated by FAO. From 32 investigated pesticides, 10 pesticides had TMDI > 65% of the ADI. Some of these ADI-exceeding compounds (spirodiclofen, abamectin, trifloxystrobin, spiromesifen, fipronil, difenoconazole, tetraconazole) were found in citrus, cucumber, grapes, tomato, and potato as the foods that have played the most roles in the consumption of these pesticides. Furthermore, a probabilistic risk assessment was performed to estimate the contingency of extravagance of the ADI. In the current research, only cyazofamid in potato for children consumers exceeded the 1 of the HQ. However, carcinogenic risk (CR) due to spirodiclofen in citrus fruit and difenoconazole in tomato was higher than the 1E-6 value; therefore, consumers were at considerable carcinogenic risk in these commodities. This scrutiny is essential for improving the activities’ risk assessment, regulation, and surveillance.

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