Enantioselective Addition of Terminal Alkynes to Isolated Isoquinoline Iminiums
Authors:
- 14 December 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 8 (1) , 143-146
Abstract
The asymmetric, catalytic addition of terminal alkynes to discrete alkyliminium species in the presence of copper bromide, QUINAP ligand, and triethylamine is reported. The reaction proceeds in high yield and high enantiomeric excess with a variety of substrates in solution and is also amenable to solid-phase synthesis.Keywords
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