Stretch‐induced increase of resting intracellular calcium concentration in single guinea‐pig ventricular myocytes

Authors:
  • EWE White
    E White
  • JAJa Argibay
    Ja Argibay
  • DGD Garnier
    D Garnier
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Abstract
Single guinea‐pig ventricular myocytes were loaded with the fluorescent Ca2+ indicator Indo‐1 AM and stretched by carbon fibres. Stretching increased resting tension. Sarcomere lengths were increased by 2‐18%. It was observed that a stretch increased resting [Ca2+]i in seven out of eight cells. The change in [Ca2+]i increased with the size of the stretch and returned to pre‐stretch levels on return to resting cell length. These observations suggest a means by which changes in resting muscle length can modify the contractile state of cardiac muscle.