Antibacterial, Fatigue-Resistant, and Self-Healing Dressing from Natural-Based Composite Hydrogels for Infected Wound Healing

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Abstract
The treatment of infected wounds faces substantial challenges due to the high incidence and serious infection-related complications. Natural-based hydrogel dressings with favorable antibacterial properties and strong applicability are urgently needed. Herein, we developed a composite hydrogel by constructing multiple networks and loading ciprofloxacin for infected wound healing. The hydrogel was synthesized via a Schiff base reaction between carboxymethyl chitosan and oxidized sodium alginate, followed by the polymerization of the acrylamide monomer. The resultant hydrogel dressing possessed a good self-healing ability, considerable compression strength, and reliable compression fatigue resistance. In vitro assessment showed that the composite hydrogel effectively eliminated bacteria and exhibited an excellent biocompatibility. In a model of Staphylococcus aureus-infected full-thickness wounds, wound healing was significantly accelerated without scars through the composite hydrogel by reducing wound inflammation. Overall, this study opens up a new way for developing multifunctional hydrogel wound dressings to treat wound infections.
Funding Information
  • State Key Laboratory of Polymer Materials Engineering (sklpme 2023-2-13)
  • National Natural Science Foundation of China (52022061)
  • 1?3?5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYJC21057)
  • the Post-Doctor Research Project, West China Hospital, Sichuan University (2023HXBH048)
  • West China Nursing Discipline Development Special Fund Project, Sichuan University (HXHL21007)

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