Emerging role of long noncoding RNA-encoded micropeptides in cancer
Open Access
- 16 October 2020
- journal article
- review article
- Published by Springer Nature in Cancer Cell International
- Vol. 20 (1) , 1-9
Abstract
Increasing evidence has indicated that long noncoding RNAs (lncRNAs) play various important roles in the development of cancers. The widespread applications of ribosome profiling and ribosome nascent chain complex sequencing revealed that some short open reading frames of lncRNAs have micropeptide-coding potential. The resulting micropeptides have been shown to participate in N6-methyladenosine modification, tumor angiogenesis, cancer metabolism, and signal transduction. This review summarizes current information regarding the reported roles of lncRNA-encoded micropeptides in cancer, and explores the potential clinical value of these micropeptides in the development of anti-cancer drugs and prognostic tumor biomarkers.Keywords
Funding Information
- National Natural Science Foundation of China (no. 81771633 and no. 81572324)
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