Evidence of a Genetic Relationship Between Susceptibility to 3-Methylcholanthrene-Induced Subcutaneous Tumors and Inducibility of Aryl Hydrocarbon Hydroxylase2

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Abstract
We found a close correlation between susceptibility to 3-methylcholanthrene (MCA)induced subcutaneous tumors and the genetically mediated presence of aryl hydrocarbon hydoxylase (AHH) induction. In a genetic system where AHH inducibility segregated as a single autosomal dominant genel mice carrying the Ahb (or inducible) allele were 5–10 times more sensitive to MCA tumorigenesis than were their non inducible (Ahd/Ahd) littermates. In backcross animals [(C57BL/6×DBA/2)×DBA/2], 10 of 12 (83%) mice with tumors were AHH inducible. This was statistically significant (P<0.025) (the expected response was 50%) and clearly indicated a relationship between this enzyme system and MCA carcinogenesis.