Acute environmental hypoxia induces LC3 lipidation in a genotype‐dependent manner

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Abstract
Hypoxia‐induced muscle wasting is a phenomenon often described with prolonged stays at high altitude, which has been attributed to altered protein metabolism. We hypothesized that acute normobaric hypoxia would induce a negative net protein balance by repressing anabolic and activating proteolytic signaling pathways at rest and postexercise and that those changes could be partially genetically determined. Eleven monozygotic twins participated in an experimental trial in normoxia and hypoxia (10.7% O 2 ). Muscle biopsy samples were obtained before and after a 20‐min moderate cycling exercise. In hypoxia at rest, autophagic flux was increased, as indicated by an increased microtubule‐associated protein 1 light chain 3 type II/I (LC3‐II/I) ratio (+25%) and LC3‐II expression (+60%) and decreased p62/SQSTM1 expression (–25%; P P P P FASEB J. 28, 1022–1034 (2014). www.fasebj.org
Funding Information
  • KU Leuven (OT/09/033)

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