Samarium Chloride Catalysed Biginelli Reaction: One-Pot synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones
Authors:
- 1 September 2002
- journal article
- research article
- Published by SAGE Publications in Journal of Chemical Research
- Vol. 2002 (9) , 436-438
Abstract
An efficient synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives using samarium chloride as a catalyst from aldehyde, β-keto ester and urea or thiourea in ethanol is described; compared to the classical Biginelli method, this new method has the advantages of good yields and milder reaction conditions.Keywords
This publication has 14 references indexed in Scilit:
- A revision of the Biginelli reaction under solid acid catalysis. Solvent-free synthesis of dihydropyrimidines over montmorillonite KSFTetrahedron Letters, 1999
- Polyphosphate Ester-Mediated Synthesis of Dihydropyrimidines. Improved Conditions for the Biginelli ReactionSynlett, 1998
- Aldol Condensation of β-Diketones and β-Ketoesters with Aldehydes Catalyzed by Samarium (III) IodideSynthetic Communications, 1996
- Enantioselective Total Synthesis of (-)-Ptilomycalin AJournal of the American Chemical Society, 1995
- 100 years of the biginelli dihydropyrimidine synthesisTetrahedron, 1993
- Hydroperfluoroalkylation of alkenes using RfI/ YbCl3 (cat.) /Zn systemTetrahedron Letters, 1993
- Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agentsJournal of Medicinal Chemistry, 1991
- 1,2-Regioselective reduction of α,β-unsaturated carbonyl compounds with lithium aluminium hydride in the presence of lanthanoid saltsJournal of the Chemical Society, Perkin Transactions 1, 1986
- Cerium chloride-promoted nucleophilic addition of grignard reagents to ketones an efficient method for the synthesis of tertiary alcoholsTetrahedron Letters, 1985
- Lanthanoids in organic synthesis. 5. Selective reductions of ketones in the presence of aldehydesJournal of the American Chemical Society, 1979