MDR1 polymorphism influences the outcome of multiple myeloma patients
Open Access
- 1 May 2007
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 137 (5) , 454-456
Abstract
The multidrug resistance gene (MDR1) has been reported to be an additional prognostic factor in acute myeloid leukaemia patients. This study evaluated the prognostic role of MDR1 in the outcome of 115 multiple myeloma patients treated with DAV (dexamethasone, doxorubicin [adryamicin] and vincristine) regimen followed by autologous transplantation. In particular, when investigating the C3435T polymorphism, a prognostic value of MDR1 genotypes for overall survival (OS) was observed. Our data suggested a longer OS for patients with C/T and T/T genotypes (log‐rank test, P = 0·02) compared with patients with C/C genotype.Keywords
This publication has 9 references indexed in Scilit:
- A "Silent" Polymorphism in the MDR 1 Gene Changes Substrate SpecificityScience, 2007
- Involvement of C3435T and G2677T multidrug resistance gene polymorphisms in release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexamethasoneEuropean Journal of Pharmacology, 2005
- The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosisBlood, 2005
- Multidrug Resistance as a Potential Prognostic Indicator in Acute Myeloid Leukemia with Normal KaryotypesActa Haematologica, 2005
- MDR1 and MRP1 gene expression are independent predictors for treatment outcome in adult acute myeloid leukaemiaBritish Journal of Haematology, 2005
- Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemiaEuropean Journal of Haematology, 2004
- Treatment of multiple myelomaBlood, 2004
- The Clinical Relevance of the Expression of Several Multidrug-Resistant-Related Genes in Patients with Primary Acute Myeloid LeukemiaJournal of Chemotherapy, 2003
- Anti-P-Glycoprotein Antibody-Induced Apoptosis of Activated Peripheral Blood Lymphocytes: A Possible Role of P-Glycoprotein in Lymphocyte SurvivalJournal of Clinical Immunology, 2001