Microbial hydroxylation of compactin (ML-236B) and monacolin K.
Authors:
- Haruyuki YamashitaHYHaruyuki Yamashita
- Saeko TsubokawaSTSaeko Tsubokawa
- Akira EndoAEAkira Endo
- 1 January 1985
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 38 (5) , 605-609
Abstract
The Basidiomycete Schizophyllum commune was found to transform compactin (ML-236B) to 8a-hydroxycompactin. This compound was isolated by solvent extraction and column chromatography, and its structure was determined by a combination of IR, UV, 1H NMR and 13C NMR spectroscopy. Monacolin K was also converted to the corresponding hydroxylated analogue. Data on the inhibition of 3-hydroxy-3-methylglutaryl co-enzyme A reductase and sterol biosynthesis in vitro are presented for these hydroxylated compounds.Keywords
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