A 42K outer-membrane protein is a component of the yeast mitochondrial protein import site
- 1 September 1989
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 341 (6239) , 205-209
Abstract
An engineered precursor protein that sticks in the import site of isolated yeast mitochondria can be specifically photo-crosslinked to a mitochondrial outer-membrane protein of relative molecular mass 42,000 (42K). This protein (termed import-site protein 42 or ISP 42) is exposed on the mitochondrial surface; antibodies against it block protein import into mitochondria. ISP 42 is the first identified component of the putative transmembrane machinery that imports proteins into mitochondria.Keywords
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