Regulation of necroptosis signaling and cell death by reactive oxygen species
Author:
- 26 February 2016
- journal article
- review article
- Published by Walter de Gruyter GmbH in Biological Chemistry
- Vol. 397 (7) , 657-660
Abstract
Necroptosis has recently been identified as an alternative form of programmed cell death that is characterized by defined molecular mechanisms. Reactive oxygen species (ROS) are involved in the regulation of numerous signaling pathways, as they are highly reactive and can cause (ir)reversible posttranslational modifications. While the role of ROS in other modes of cell death has been extensively studied, its impact on necroptotic signaling and cell death is far less clear. The current minireview discusses the evidence for and against a role of ROS in necroptosis.Keywords
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