Antibody‐Functionalized Hybrid Superparamagnetic Nanoparticles

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Abstract
Superparamagnetic hybrid nanoparticles (ca. 80 nm) are obtained. They consist of an inner iron oxide core coated by a silica shell, which is in turn functionalized with amine or carboxyl groups and covalently coupled to a monoclonal antibody (anti‐hCG; hCG = human chorionic gonadotropin). The prepared nanoparticles show a specific magnetic moment (per gram of iron) that is comparable to that measured for commercial superparamagnetic iron oxide preparations. The bioactivity of the antibody‐conjugated magnetic nanoparticles is verified by a standard bioassay. These results indicate the potential of the hybrid nanoparticles prepared for use as enhanced contrast agents in magnetic resonance imaging applications.
Funding Information
  • Spanish Nanoscience Action (NAN200409270C3-1/2)
  • Consolider Program (CSD2006-00012)
  • “Juan de la Cierva” Program (PPQ2003-04986)
  • “Ramón y Cajal” program

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