Experiments with Fractionated X-irradiation of the Skin of Pigs II. – Fractionation up to Five Days

Authors:
  • JFJ. F. Fowler
    J. F. Fowler
  • DBD. K. Bewley
    D. K. Bewley
  • RMR. L. Morgan
    R. L. Morgan
  • JSJ. A. Silvester
    J. A. Silvester
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Abstract
Fifteen fields on one pig were irradiated with 1, 2, 2, 3 and 5 fractions in 1, 5, 2, 3 and 5 days respectively. Skin reactions were recorded up to 80 or 100 days, so that the doses which produced equal reactions could be assessed. Three degrees of damage were analysed for early, medium and late reactions. As an example, the doses to produce one level of reaction over 30–85 days were respectively 2,050, 2,560–2,750, 2,750, 3,360 and 4,060 rads for the fractions listed above. The corresponding values of “DQ” = (Dn — D1)/(n —; 1) were high, 500–700 rads. The values of (Dn − D1)/(n − 1) became smaller with larger numbers of fractions. Two pigs were irradiated to investigate the “reciprocal vicinity” effect. It was found to be small for the field arrangements used, but the sensitivity of pig skin increased in the dorso-ventral direction and corrections were sometimes necessary. Two pigs were irradiated with pairs of equal doses separated by 0 to 24 hours. A recovery pattern was observed similar to that found ...

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