HPV infection of the male urogenital tract: is there aa association with infertility and chronic prostatitis?

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Abstract
Introduction. The role of human papilloma viruses is well-studied in a number of cancers. However, the role of urogenital HPV infection and its association with pathospermia, male infertility, and genitourinary tract inflammatory diseases are understudied. Objective. To determine the prevalence of HPV in patients with chronic prostatitis and infertility. Materials and methods. Quantitative PCR was used to detect high carcinogenic risk (HCR) HPV in the ejaculate of 489 males aged 22–65. Group 1 included infertile males with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), Group 2 included males with idiopathic infertility (without CP/CPPS), Group 3 included fertile males with CP/CPPS, Group 4 included healthy fertile males (control group). Results. 64 (14.6%) of the examined males had HPV. None of the males from the control group had HCR HPV in the ejaculate. Group 1 had a significantly higher number of all HPV genotypes (40 (22.2%) of 180) than Group 2 (25 (14.3%) of 175) and Group 3 (13 (15.9%) of 82). HPV viral load was highest in Group 3 (~2500 copies/100.000 cells). Conclusion. HCR HPV is associated with male infertility and chronic prostatitis/chronic pelvic pain syndrome. The association of mixed infection with various HPV types with infertility and high HPV viral load with CP/CPPS was shown.

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