Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer.
Authors:
- P W KantoffP W Kantoff
- A P GillioAGA P Gillio
- J R McLachlinJMJ R McLachlin
- C BordignonCBC Bordignon
- M A EglitisMEM A Eglitis
- N A KernanNKN A Kernan
- R C MoenRMR C Moen
- D B KohnD B Kohn
- S F YuSYS F Yu
- E KarsonEKE Karson
Open Access
- 1 July 1987
- journal article
- research article
- Published by Rockefeller University Press in Journal of Experimental Medicine
- Vol. 166 (1) , 219-234
Abstract
Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals. Several monkeys fully reconstituted and were shown to express the h-ADA and neor genes at low levels in their recirculating hematopoietic cells for short periods of time.Keywords
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