International Union of Pharmacology. LXVI. Orphan Nuclear Receptors
Authors:
- Gérard BenoitGBGérard Benoit
- Austin CooneyACAustin Cooney
- Vincent GiguereVGVincent Giguere
- Holly IngrahamHIHolly Ingraham
- Mitch LazarMLMitch Lazar
- George MuscatGMGeorge Muscat
- Thomas PerlmannTPThomas Perlmann
- Jean-Paul RenaudJRJean-Paul Renaud
- John SchwabeJSJohn Schwabe
- Frances SladekFSFrances Sladek
- Ming-Jer TsaiMTMing-Jer Tsai
- Vincent LaudetVLVincent Laudet
- 1 December 2006
- journal article
- review article
- Published by Elsevier in Pharmacological Reviews
- Vol. 58 (4) , 798-836
Abstract
Half of the members of the nuclear receptors superfamily are so-called “orphan” receptors because the identity of their ligand, if any, is unknown. Because of their important biological roles, the study of orphan receptors has attracted much attention recently and has resulted in rapid advances that have helped in the discovery of novel signaling pathways. In this review we present the main features of orphan receptors, discuss the structure of their ligand-binding domains and their biological functions. The paradoxical existence of a pharmacology of orphan receptors, a rapidly growing and innovative field, is highlighted.Keywords
This publication has 467 references indexed in Scilit:
- The Drosophila Nuclear Receptor E75 Contains Heme and Is Gas ResponsiveCell, 2005
- Induction of apolipoprotein E expression by TR4 orphan nuclear receptor via 5′ proximal promoter regionBiochemical and Biophysical Research Communications, 2005
- A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian ClockNeuron, 2004
- Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRγBiochemical and Biophysical Research Communications, 2003
- The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian OscillatorCell, 2002
- Transitional change in interaction between HIF-1 and HNF-4 in response to hypoxiaJournal of Human Genetics, 1999
- Identification of the Human Aldolase A Gene as the First Induced Target for the TR2 Orphan Receptor, a Member of the Steroid Hormone Receptor SuperfamilyBiochemical and Biophysical Research Communications, 1997
- Differential Activation of the Murine Laminin B1 Gene Promoter by RARα, RORα, and AP-1Biochemical and Biophysical Research Communications, 1996
- The RXR heterodimers and orphan receptorsCell, 1995
- Identification of a new member of the steroid receptor super-family by cloning and sequence analysisBiochemical and Biophysical Research Communications, 1988