Linker-mediated self-assembly of mobile DNA coated colloids

Authors:
  • XXXiuyang Xia
    Xiuyang Xia
  • HHHao Hu
    Hao Hu
  • MCMassimo Pica Ciamarra
    Massimo Pica Ciamarra
  • RNRan Ni
    Ran Ni

Abstract
An immense challenge in materials science is to find a way to construct materials with absolute control over the placement of each building block in order to tailor properties for given applications. In past decades, DNA coated colloids offer the possibility of realizing programmable self-assembly, which in principle can assemble almost any structure in equilibrium, while remains challenging experimentally. Here we propose a new system of linker-mediated mobile DNA coated colloids (mDNACCs), in which the interaction between mDNACCs is induced by bridging of free DNA linkers in solution, whose two single stranded DNA tails can bind with specific single stranded DNA receptors of complementary sequence coated on the colloids. We formulate a mean field theory to efficiently calculate the effective interaction between mDNACCs mediated by free DNA linkers, in which the entropy of DNA linkers plays a non-trivial role. Especially, when the binding between free DNA linkers in solution and the corresponding receptors on mDNACCs is very strong, the linker-mediated colloidal interaction is determined by the linker entropy, which depends only on the concentration of free DNA linkers. As the concentration of free DNA linkers can be precisely controlled in experiments, this suggests a new way for experimentally addressable self-assembly of DNA coated colloids.