Excavatolides U−Z, New Briarane Diterpenes from the Gorgonian Briareum excavatum
Authors:
- 18 September 1999
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 62 (10) , 1415-1420
Abstract
A recent study of the EtOAc extract of the gorgonian Briareum excavatum afforded six new diterpenes of the briarane skeleton, excavatolides U−Z (1−6). The structures and relative stereochemistry of metabolites 1−6 were assigned on the basis of NMR studies and chemical methods. The structure, including the relative configuration of excavatolide U (1), was further confirmed by a single-crystal X-ray analysis. Some of the excavatolides have displayed significant cytotoxicity toward P-388 and HT-29 tumor cells.Keywords
This publication has 11 references indexed in Scilit:
- Briarane Diterpenes from the Indian Ocean Gorgonian Gorgonella umbraculumJournal of Natural Products, 1998
- Further briareolate esters and briareolides from the Caribbean gorgonian octocoral Briareum asbestinumTetrahedron, 1996
- New Diterpenes from the Gorgonian Solenopodium excavatumJournal of Natural Products, 1993
- Diterpenoids from the gorgonian Solenopodium stecheiThe Journal of Organic Chemistry, 1992
- New briarein diterpenes from the Caribbean gorgonians Erythropodium caribaeorum and Briareum spThe Journal of Organic Chemistry, 1991
- Tubiporein, a novel diterpene from a japanese soft coral tubipora sp.Tetrahedron Letters, 1990
- The junceellolides, new anti-inflammatory diterpenoids of the briarane class from the chinese gorgonian junceella fragilisTetrahedron, 1989
- Brianthein V, a New Cytotoxic and Antiviral Diterpene Isolated from Briareum asbestinumJournal of Natural Products, 1988
- Renillafoulins, antifouling diterpenes from the sea pansy Renilla reniformis (Octocorallia)The Journal of Organic Chemistry, 1986
- Structure and stereochemistry of insecticidal diterpenes from the sea penXXXTetrahedron, 1986