The cDNAs coding for the α‐ and β‐subunits of Xenopus laevis casein kinase II
Authors:
- Maria Victoria HinrichsMHMaria Victoria Hinrichs
- Catherine C. AllendeCACatherine C. Allende
- Jorge E. AllendeJAJorge E. Allende
- 10 February 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 297 (3) , 280-284
Abstract
Using a λgt10 cDNA library obtained from Xenopus laevis oocytes and probes derived from the known sequences of the human and Drosophila genes, a cDNA coding for the α‐subunit of the X. laevis casein kinase II was isolated. The coding sequence of this clone determines a polypeptide of 350 amino acids. The X. laevis sequence is 98% identical to the human and rat proteins in the first 323 amino acids. Using the polymerase chain reaction to generate a 370‐nucleotide‐long probe, it was possible to clone and sequence a cDNA of 900 nucleotides that coded for the X. laevis β‐subunit of casein kinase II. The derived protein sequence is 215 amino acids long and again shows an extraordinary degree of conservation with other species.Keywords
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