Amplified Photoacoustic Signal and Enhanced Photothermal Conversion of Polydopamine-Coated Gold Nanobipyramids for Phototheranostics and Synergistic Chemotherapy

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Abstract
Light-responsive nanoprobes were suffering from the threat of high-lose laser irradiation, and it was important of constructing new nanoprobes for safe and efficient photo-theranostics. Here, polydopamine (PDA)-coated gold nanobipyramids ([email protected]) were synthesized for amplified photoacoustic (PA) signal and enhanced photothermal conversion with low-dose laser irradiation, and then doxorubicin (DOX)-loaded [email protected] nanoprobes were constructed for PA imaging-guided synergistic photothermal therapy (PTT) and chemotherapy. The [email protected] nanoparticles possessed higher photothermal conversion efficiency (42.07%) and stronger PA signal than AuNBPs nanoparticles, and the [email protected] nanoprobes showed dual-responsive DOX release of pH and photothermal stimulation. With the low-dose laser irradiation (1.0 W/cm2) and low-concentration [email protected] (60 µg/mL), the 4T1 cell viability was reduced to about 5%, owing to the combination of PTT and chemotherapy, compared with 42.3% of single chemotherapy and 25.3% of single PTT. Moreover, by modelling 4T1 tumor-bearing nude mice, the in vivo PA imaging was achieved, and the tumors were completely inhibited, demonstrating the excellent synergistic effect of PTT/chemotherapy. Therefore, the developed [email protected] nanoprobes can be used for photo-theranostics and synergistic chemotherapy, achieving low-dose laser irradiation and high-efficient visualized theranostics.
Funding Information
  • Ministry of Science and Technology of the People's Republic of China (2018YFC0910601, SQ2019YFA040008-03)
  • Department of Education of Hebei Province (BJ2017002)
  • National Natural Science Foundation of China (31971292, 51772074, U1332117, U1732127)
  • Hebei Provincial Department of Science and Technology (17961302D)
  • Undergraduate? Innovation and Entrepreneurship Training Program of Hebei University (2020051)
  • Advanced Talents Incubation Program of Hebei University (521000981076)

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