Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway
Authors:
Open Access
- 1 April 2020
- journal article
- research article
- Published by Taylor & Francis in Drug Design, Development and Therapy
- Vol. ume 14, 1633-1639
Abstract
Purpose: The aim of the experiment was to explore the effect of eriodictyol (ERI) on arthritis. Methods: We established a rat model of collagen-induced rheumatoid arthritis (CIA) using type II collagen plus Freund’s complete adjuvant. We evaluated the degree of paw swelling, joint pathology, inflammatory cytokine levels, and the Akt/hypoxia-inducible factor (HIF)-1α signaling pathway in the CIA rats. Results: ERI significantly ameliorated joint swelling; improved joint pathology; and suppressed the release of interleukin-6, interleukin-1 beta, and tumor necrosis factor-alpha. Moreover, ERI inhibited the Akt/HIF-1α pathway in the joints of rats and in lipopolysaccharide-treated RAW264.7 cells. Conclusion: ERI ameliorated arthritis in a manner involving the Akt/HIF-1α signaling pathway.Keywords
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