Benign chronic bullous dermatosis of childhood. Linear IgA and C3 deposition on the basement membrane

Authors:
  • SPS Prystowsky
    S Prystowsky
  • JGJ N Gilliam
    J N Gilliam
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Abstract
Benign chronic bullous dermatosis of childhood (BCBDC) is characterized by predominantly monomorphous, large, tense bullae with a predilection for the lower part of the trunk, the pelvic region and the lower extremities. Most patients have blisters for 2-3 yr and experience spontaneous exacerbations and remissions. This is apparently the first known case in which a linear band of IgA [immunoglobulin A] (but no IgG or IgM) and complement were found at the epidermal basal lamina, as demonstrated by immunofluorescence studies.