A Hypothesis for the Mode of Action of α-Methyldopa in Relieving Hypertension
Authors:
- 1 September 1963
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 15 (1) , 221-224
Abstract
There is evidence that α-methyldopa can serve as the precursor of α-methylnoradrenaline in the body. The α-methylnoradrenaline so formed may enter noradrenaline storage sites and then be released as a false neuro-transmitter. Because of the lesser potency of α-methylnoradrenaline there is some loss of responsiveness to sympathetic nerve stimulation which can explain the lowering of blood pressure in hypertensive patients.Keywords
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