Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation
Authors:
- Maria V. SelvaduraiMSMaria V. Selvadurai
- Mitchell J. MoonMMMitchell J. Moon
- Simon J. MountfordSMSimon J. Mountford
- Xiao MaXMXiao Ma
- Ian G. JenningsIJIan G. Jennings
- Natasha M. SetiabaktiNSNatasha M. Setiabakti
- Nurul Aisha Z. AbidinNANurul Aisha Z. Abidin
- Gaëtan ChicanneGCGaëtan Chicanne
- Sonia SeverinSSSonia Severin
- 22 July 2020
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Translational Medicine
- Vol. 12 (553)
Abstract
First-generation PI3KC2α inhibitors prevent thrombosis without causing bleeding.Keywords
Funding Information
- Australian Research Council (FT130100540)
- National Health and Medical Research Council (1047295)
- Cass Foundation (SM16/7334)
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