The effects of tofisopam, a 3,4‐benzodiazepine, in animal models of anziety, sedation, and convulsions

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Abstract
Tofisopam, a 3, 4‐benzodiazepine classified as a nonsedative anxiolytic in man, had no effect in two animal tests of anxiety (the social interaction test and a punished drinking test; 10‐‐50 mg/kg) and produced a dose‐related reduction in exploratory and locomotor activity in the holeboard (5‐‐100 mg/kg). These reductions were not antagonised by chlordiazepoxide (5 mg/kg), Ro 15‐‐1788 (10‐‐20 mg/kg), or picrotoxin (2 mg/kg); however, the reductions in head‐dipping but not in motor activity or rears were antagonised by CGS 8216 (10 mg/kg). Tofisopam (10‐‐50 mg/kg) had no anticonvulsant activity, but had proconvulsant activity, with picrotoxin and pentylenetetrazole. In contrast, tofisopam (50‐‐100 mg/kg) antagonised the convulsions induced by the 1, 4‐benzodiazepine Ro 5‐‐4864.

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