Alteration of the Repressor Activity of MarR, the Negative Regulator of the Escherichia coli marRAB Locus, by Multiple Chemicals In Vitro
Authors:
- 1 August 1999
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 181 (15) , 4669-4672
Abstract
MarR negatively regulates expression of the multiple antibiotic resistance operon ( marRAB ) in Escherichia coli . In this study, it was demonstrated that sodium salicylate, plumbagin, 2,4-dinitrophenol, and menadione–inducers of the marRAB operon in whole cells–all interfered with the repressor activity of MarR in vitro. It is proposed that these compounds can interact directly with MarR to affect its repressor activity.Keywords
This publication has 31 references indexed in Scilit:
- Molecular basis of triclosan activityNature, 1999
- Structural Basis of Multidrug Recognition by BmrR, a Transcription Activator of a Multidrug TransporterCell, 1999
- Multidrug Efflux Pump AcrAB of Salmonella typhimurium Excretes Only Those β-Lactam Antibiotics Containing Lipophilic Side ChainsJournal of Bacteriology, 1998
- Broad Ligand Specificity of the Transcriptional Regulator of theBacillus subtilisMultidrug Transporter BmrBiochemical and Biophysical Research Communications, 1997
- Expression of a Butyrivibrio fibrisolvens E14 gene (cinB) encoding an enzyme with cinnamoyl ester hydrolase activity is negatively regulated by the product of an adjacent gene (cinR)Microbiology, 1997
- Isolation of an oxygen-sensitive FNR protein of Escherichia coli: interaction at activator and repressor sites of FNR-controlled genes.Proceedings of the National Academy of Sciences, 1996
- Binding of purified multiple antibiotic-resistance repressor protein (MarR) to mar operator sequences.Proceedings of the National Academy of Sciences, 1995
- Multidrug resistance pumps in bacteria: variations on a themeTrends in Biochemical Sciences, 1994
- [6] Use of T7 RNA polymerase to direct expression of cloned genes1990
- Purification and characterization of trp aporepressor.Proceedings of the National Academy of Sciences, 1983