Effect of PMX‐DHP for sepsis due to ESBL‐producing E. coli in an extremely low‐birthweight infant
Authors:
- 29 December 2015
- journal article
- case report
- Published by Wiley in Pediatrics International
- Vol. 58 (5) , 411-414
Abstract
We report a case of early onset sepsis caused by (CTX for cefotaximase and M for Munich)‐type extended‐spectrum β‐lactamase‐producing Escherichia coli (ESBL E. coli) in a preterm infant weighing 601 g. He was given meropenem and treated for endotoxin absorption with polymyxin B‐immobilized fibers with only 8 mL of priming volume. The patient survived without any short‐term neurological or respiratory sequelae. The choice of antibiotics is particularly important in seriously ill neonates with sepsis due to ESBL‐producing organisms. Polymyxin B hemoperfusion might be an innovative therapy for severe neonatal sepsis and could improve outcome even in an extremely low‐birthweight infant.Keywords
This publication has 10 references indexed in Scilit:
- Ceftolozane/tazobactam activity tested against aerobic Gram-negative organisms isolated from intra-abdominal and urinary tract infections in European and United States hospitals (2012)Journal of Infection, 2014
- Polymyxin B hemoperfusion: a mechanistic perspectiveCritical Care, 2014
- Risk Factors and Outcomes for Multidrug-Resistant Gram-Negative Bacteremia in the NICUPediatrics, 2014
- Early-Onset Neonatal SepsisClinical Microbiology Reviews, 2014
- Molecular characteristics of extended-spectrum β-lactamase-producing Escherichia coli in Japan: emergence of CTX-M-15-producing E. coli ST131Diagnostic Microbiology and Infectious Disease, 2012
- A 7-year surveillance for ESBL-producingEscherichia coliandKlebsiella pneumoniaeat a university hospital in Taiwan: the increase of CTX-M-15 in the ICUEpidemiology and Infection, 2009
- A rapid enzyme‐linked immunosorbent assay with two modes of detection for measuring cytokine concentrationJournal of Clinical Laboratory Analysis, 2009
- Effect of Nosocomial Infections Due to Antibiotic-Resistant Organisms on Length of Stay and Mortality in the Pediatric Intensive Care UnitInfection Control & Hospital Epidemiology, 2007
- International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics*Pediatric Critical Care Medicine, 2005
- Antibiotic Therapy for Klebsiella pneumoniae Bacteremia: Implications of Production of Extended-Spectrum -LactamasesClinical Infectious Diseases, 2004