A human cell atlas of fetal chromatin accessibility

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Abstract
The genomics of human development: Understanding the trajectory of a developing human requires an understanding of how genes are regulated and expressed. Two papers now present a pooled approach using three levels of combinatorial indexing to examine the single-cell gene expression and chromatin landscapes from 15 organs in fetal samples. Cao et al. focus on measurements of RNA in broadly distributed cell types and provide insights into organ specificity. Domcke et al. examined the chromatin accessibility of cells from these organs and identify the regulatory elements that regulate gene expression. Together, these analyses generate comprehensive atlases of early human development. Science , this issue p. eaba7721 , p. eaba7612
Funding Information
  • National Institutes of Health (NICHD R24HD000836)
  • European Molecular Biology Organization
  • Human Frontier Science Program
  • NHLBI (T32HL007828)
  • Allen Discovery Center
  • Allen Discovery Center
  • Brotman Baty Institute for Precision Medicine

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