Epidemiological Interactions between Urogenital and Intestinal Human Schistosomiasis in the Context of Praziquantel Treatment across Three West African Countries

Authors:
Open Access
Publisher website
Google Scholar
Abstract
In many parts of sub-Saharan Africa, urogenital and intestinal schistosomiasis co-occur, and mixed species infections containing both Schistosoma haematobium and S. mansoni can be common. During co-infection, interactions between these two species are possible, yet the extent to which such interactions influence disease dynamics or the outcome of control efforts remains poorly understood. Here we analyse epidemiological data from three West African countries co-endemic for urogenital and intestinal schistosomiasis (Senegal, Niger and Mali) to test whether the impact of praziquantel (PZQ) treatment, subsequent levels of re-infection or long-term infection dynamics are altered by co-infection. In all countries, positive associations between the two species prevailed at baseline: infection by one species tended to predict infection intensity for the other, with the strength of association varying across sites. Encouragingly, we found little evidence that co-infection influenced PZQ efficacy: species-specific egg reduction rates (ERR) and cure rates (CR) did not differ significantly with co-infection, and variation in treatment success was largely geographical. In Senegal, despite positive associations at baseline, children with S. mansoni co-infection at the time of treatment were less intensely re-infected by S. haematobium than those with single infections, suggesting competition between the species may occur post-treatment. Furthermore, the proportion of schistosome infections attributable to S. mansoni increased over time in all three countries examined. These findings suggest that while co-infection between urinary and intestinal schistosomes may not directly affect PZQ treatment efficacy, competitive interspecific interactions may influence epidemiological patterns of re-infection post-treatment. While re-infection patterns differed most strongly according to geographic location, interspecific interactions also seem to play a role, and could cause the community composition in mixed species settings to shift as disease control efforts intensify, a situation with implications for future disease management in this multi-species system. In many parts of Africa both urinary and intestinal schistosomiasis are endemic, and mixed species infections can be common. However, little is known about potential within-host interactions between the causative parasites, S. haematobium and S. mansoni, and how these might influence treatment success and post-treatment patterns of re-infection. Here, we bring together datasets from three West African countries to examine the epidemiological evidence for interactions between these two schistosome species relevant to the impact of treatment programmes using praziquantel (PZQ). Encouragingly, PZQ efficacy (in a double 40mg/kg dose format) was not significantly altered by co-infection, though since co-infections tended to be heavier, complete clearance was less likely than for single species infections. Despite positive associations in infection intensity for these two species at baseline, Senegalese children that were successfully treated for S. haematobium showed less intense re-infection if they were co-infected with S. mansoni at the point of treatment. Furthermore, in all three settings, the proportion of infections attributable to S. mansoni increased over successive rounds of PZQ treatment. These data suggest asymmetric competition may occur between S. haematobium and S. mansoni in the context of drug treatment, which may alter schistosome species composition as PZQ-based control programmes proceed.

This publication has 50 references indexed in Scilit: