Inhibition of phosphatidylinositol kinase-III alpha induces or facilitates lysosome exocytosis from microglia.
- 10 July 2020
- journal article
- research article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 31 (10) , 697-701
Abstract
Besides degradation, lysosomes can also carry molecules for secretion out of the cell, such as ATP and cytokines, during unconventional secretion. Phosphatidylinositols and their metabolizing enzymes play important roles in the sorting and trafficking of lysosomal materials through the trans-Golgi network. The present study reveals a new function of phosphatidylinositol kinase-III alpha in the 'kiss-and-run' fusion of lysosomes at the plasma membrane to release ATP from microglia.Keywords
This publication has 15 references indexed in Scilit:
- The lipid kinase PI4KIIIβ preserves lysosomal identityThe EMBO Journal, 2012
- PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identityJournal of Cell Biology, 2012
- Phosphatidylinositol 4-Kinases and PI4P Metabolism in the Nervous System: Roles in Psychiatric and Neurological DiseasesMolecular Neurobiology, 2012
- Phosphoinositides in Golgi Complex Function2012
- Phosphoinositides in the Mammalian Endo-lysosomal Network2012
- Microglial migration mediated by ATP-induced ATP release from lysosomesCell Research, 2012
- Regulated ATP release from astrocytes through lysosome exocytosisNature Cell Biology, 2007
- Phosphatidylinositol 4-kinases: old enzymes with emerging functionsTrends in Cell Biology, 2006
- Frequency-Dependent Kinetics and Prevalence of Kiss-and-Run and Reuse at Hippocampal Synapses Studied with Novel Quenching MethodsNeuron, 2006
- Storage and Release of ATP from Astrocytes in CultureJournal of Biological Chemistry, 2003