The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiation
- 11 July 2008
- journal article
- Published by Springer Nature in Nature Neuroscience
- Vol. 11 (8) , 868-870
Abstract
Corticosterone facilitates hippocampal glutamate transmission, but the cellular pathways by which AMPA receptor (AMPAR) signaling is adjusted remain elusive. Single quantum-dot imaging in live rat hippocampal neurons revealed that corticosterone triggers, via distinct corticosteroid receptors, time-dependent increases in GluR2-AMPAR surface mobility and synaptic surface GluR2 content. Furthermore, corticosterone potentiates the increase of synaptic surface GluR2 contents by a chemical long-term potentiation stimulus, revealing the influence that corticosterone has on AMPAR trafficking.Keywords
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