Chromosomal Localization of Muscle Nicotinic Acetylcholine Receptor Genes in the Mouse
Authors:
- 14 November 1986
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 234 (4778) , 866-868
Abstract
The chromosomal localization of the genes encoding the four subunits of muscle nicotinic receptor was determined by analyzing restriction fragment length polymorphisms between two mouse species Mus musculus domesticus (DBA/2) and Mus spretus (SPE). Analysis of the progeny of the interspecies mouse backcross (DBA/2 × SPE) × DBA/2 showed that the α-subunit gene cosegregates with the α-cardiac actin gene on chromosome 17, that the β-subunit gene is located on chromosome 11, and that the γ- and δ-subunit genes cosegregate and are located on chromosome 1.Keywords
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