Identification of a monoclonal antibody specific for a murine T3 polypeptide.
Authors:
- O LeoOLO Leo
- M FooMFM Foo
- D H SachsDSD H Sachs
- L E SamelsonLSL E Samelson
- J A BluestoneJBJ A Bluestone
- 1 March 1987
- journal article
- research article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 84 (5) , 1374-1378
Abstract
A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific for a 25-kDa protein component (T3-epsilon) of the antigen-specific T-cell receptor. It reacts with all mature T cells and can both activate and inhibit T-cell function. These results identify T3-epsilon as a cell surface protein involved in the transduction of activation signals.Keywords
This publication has 30 references indexed in Scilit:
- Identification of monoclonal antibodies specific for the T cell receptor complex by Fc receptor-mediated CTL lysis.The Journal of Immunology, 1986
- Identification of a putative second T-cell receptorNature, 1986
- Interleukin 2 receptor expression in unstimulated murine splenic T cells. Localization to L3T4+ cells and regulation by non-H-2-linked genes.Journal of Experimental Medicine, 1986
- The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen RecognitionAnnual Review of Immunology, 1986
- A T3-like protein complex associated with the antigen receptor on murine T cellsNature, 1986
- Transfer of specificity by murine α and β T-cell receptor genesNature, 1986
- Identification of the components of the murine T cell antigen receptor complexCell, 1985
- Selective activation of Lyt 2+ precursor T cells by ligation of the antigen receptorNature, 1985
- Lysis of anti-T3-bearing murine hybridoma cells by human allospecific cytotoxic T cell clones and inhibition of that lysis by anti-T3 and anti-LFA-1 antibodies.The Journal of Immunology, 1985
- A 20-kDa protein associated with the murine T-cell antigen receptor is phosphorylated in response to activation by antigen or concanavalin A.Proceedings of the National Academy of Sciences, 1985