Elastofibromatous changes in giant cell fibroma and amalgam tattoo: Unusual findings in common oral lesions

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Abstract
Several cases of elastofibromatous lesion affecting the oral mucosa have been reported. Clinically, these lesions may appear as small exophytic lesions or less often as white lesions. Therefore, fibrous hyperplasia and leukoplakia are not uncommonly considered in clinical differential diagnosis. Microscopically, elastic and fibrous connective tissue deposition is seen. Rarely, elastofibromatous changes can be detected when assessing intraoral lesions, including cysts, salivary gland neoplasms, and epithelial dysplasia. Here we report two oral lesions showing elastofibromatous changes, expanding their clinicopathological spectrum. The first case was a 46-year-old man with a history of asymptomatic nodular lesion on the palate 1 year ago, diagnosed as giant cell fibroma with elastofibromatous changes. The second case was a 79-year-old woman who presented a pigmented and mildly symptomatic lesion on the mandibular alveolar mucosa several months ago, diagnosed as amalgam tattoo associated with elastofibromatous changes.
Funding Information
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2016/11419‐0, 2022/07479‐9, 2022/12760‐9)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (304241/2021‐0)
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Finance Code 001)

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