Encapsulation of goji berry extract in nanoliposomes with antitumor effect: A comparative study of unsaturated and hydrogenated lipids via the ethanol injection method

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Abstract
Goji berry ( Lycium barbarum ) extract, rich in bioactive compounds, was encapsulated in liposomes prepared with either unsaturated or hydrogenated lipids. Their physicochemical properties and antitumor activity were then evaluated. The liposomes exhibited particle sizes of 77.49 ± 3.09 and 129.4 ± 4.1 nm when prepared with hydrogenated and unsaturated phospholipids, respectively. In both cases, a 5% (w/w) extract loading superior results compared to 10% and 20% loading for both lipids types. The encapsulation efficiency was higher for unsaturated phospholipids than for hydrogenated ones. Nevertheless, both lipids formed unilamellar vesicles with over 80% release after 24 h. The liposome systems displayed antiproliferative activity against cancer cells, and cell viability was lower with extract‐loaded liposomes than with free extract, demonstrating the benefits of encapsulation. Thus, this study confirms the viability and applicability of goji berry extract encapsulation.
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  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

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