Highly Selective Synthesis of Pillar[n]arene (n = 5, 6)
- 10 October 2018
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 20 (20) , 6583-6586
Abstract
An efficient and highly selective synthetic method toward the preparation of pillar[n]arenes (n = 5, 6) is reported, based upon a high solvent-dependent selectivity found in the condensation reaction between 1,4-dialkyloxybenzene and paraformaldehyde, involving methanesulfonic acid as catalyst. Pillar[6]arene (P6) is obtained as the major product when using chloroform as solvent, while in dichloromethane pillar[5]arene (P5) is the dominant product. Accordingly, a series of P5 and P6 have been selectively synthesized with excellent yield.Keywords
Funding Information
- National Science Foundation (CHE-1508677)
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